| 4. Round | 16/03/2025 | St. Louis City SC | - | Seattle Sounders | 1:0 | ||||
| 5. Round | 22/03/2025 | Philadelphia Union | - | St. Louis City SC | 1:0 | ||||
| 6. Round | 30/03/2025 | St. Louis City SC | - | Austin FC | 0:1 | ||||
| 7. Round | 06/04/2025 | Sporting Kansas City | - | St. Louis City SC | 2:0 | ||||
| 8. Round | 14/04/2025 | St. Louis City SC | - | Columbus Crew | 1:2 | ||||
| 9. Round | 20/04/2025 | St. Louis City SC | - | Vancouver Whitecaps | 0:0 | ||||
| 10. Round | 28/04/2025 | Los Angeles FC | - | St. Louis City SC | 2:2 | ||||
| 11. Round | 04/05/2025 | Seattle Sounders | - | St. Louis City SC | 4:1 | ||||
| 12. Round | 11/05/2025 | St. Louis City SC | - | San Diego FC | 1:2 |
Germany