| 1. Round | 10/01/2021 | Deportivo Toluca [U20] | - | Gallos Blancos [U20] | 1:2 | ||||
| 9. Round | 02/03/2021 | UANL Tigres [U20] | - | Deportivo Toluca [U20] | 0:0 | ||||
| 11. Round | 14/03/2021 | Deportivo Toluca [U20] | - | CF Pachuca [U20] | 2:1 |  |
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| 12. Round | 21/03/2021 | Deportivo Toluca [U20] | - | Puebla FC [U20] | 1:2 | ||||
| 14. Round | 11/04/2021 | Deportivo Toluca [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 15. Round | 18/04/2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:2 | ||||
| 16. Round | 25/04/2021 | Deportivo Toluca [U20] | - | CF América [U20] | 0:2 | ||||
| 17. Round | 30/04/2021 | FC Juárez [U20] | - | Deportivo Toluca [U20] | 0:0 | |
Mexico