| 1. Round | 16/03/2022 | América de Quito | - | Atlético Santo Domingo | 0:0 | ||||
| 2. Round | 23/03/2022 | Atlético Santo Domingo | - | Independiente Juniors | 0:1 | ||||
| 3. Round | 27/03/2022 | Imbabura | - | Atlético Santo Domingo | 2:0 |  |
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| 4. Round | 31/03/2022 | Atlético Santo Domingo | - | Manta | 2:0 | ||||
| 6. Round | 15/04/2022 | Libertad de Loja | - | Atlético Santo Domingo | 1:1 | |
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| 7. Round | 20/04/2022 | Atlético Santo Domingo | - | El Nacional | 1:1 | |
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| 8. Round | 27/04/2022 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 | |
Spain