| Zona B | 21/02/2021 | Cobán Imperial | - | CSD Municipal | 1:0 | ||||
| Zona B | 28/02/2021 | Achuapa | - | Cobán Imperial | 2:1 | ||||
| Zona B | 03/03/2021 | Cobán Imperial | - | Sacachispas | 2:2 |  |
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| Zona B | 06/03/2021 | Cobán Imperial | - | Sanarate | 2:0 | |
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| Zona B | 10/03/2021 | Deportivo Guastatoya | - | Cobán Imperial | 1:1 | ||||
| Zona B | 13/03/2021 | CSD Municipal | - | Cobán Imperial | 2:0 | ||||
| Zona B | 07/04/2021 | Sanarate | - | Cobán Imperial | 0:0 | ||||
| Zona B | 10/04/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
| Interzone | 14/04/2021 | Cobán Imperial | - | Iztapa | 2:2 | ||||
| Interzone | 17/04/2021 | Santa Lucía | - | Cobán Imperial | 1:1 | |
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| Interzone | 21/04/2021 | Cobán Imperial | - | Xelaju MC | 0:0 | ||||
| Interzone | 25/04/2021 | Deportivo Malacateco | - | Cobán Imperial | 0:0 | ||||
| Interzone | 28/04/2021 | Cobán Imperial | - | Antigua GFC | 4:2 | |
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| Interzone | 02/05/2021 | Comunicaciones | - | Cobán Imperial | 1:1 | ||||
| Quarter-finals | 06/05/2021 | Cobán Imperial | - | Santa Lucía | 1:1 | ||||
| Quarter-finals | 09/05/2021 | Santa Lucía | - | Cobán Imperial | 3:0 |
Colombia
El Salvador