 |
 |
|
|
| 1st(1st leg) | Sanarate | - | Deportivo Guastatoya | 2:0 (2:0) | ||
| 2nd (2nd leg) | Deportivo Guastatoya | - | Sanarate | 4:1 (0:0) | ||
| 1st(1st leg): 05/05/2021 20:00 | 2nd (2nd leg): 08/05/2021 22:00 | Winner: Deportivo Guastatoya | ||||
| 1st(1st leg) | Sacachispas | - | Comunicaciones | 0:1 (0:1) | ||
| 2nd (2nd leg) | Comunicaciones | - | Sacachispas | 1:0 (0:0) | ||
| 1st(1st leg): 06/05/2021 02:00 | 2nd (2nd leg): 09/05/2021 01:00 | Winner: Comunicaciones | ||||
| 1st(1st leg) | Iztapa | - | CSD Municipal | 3:1 (1:0) | ||
| 2nd (2nd leg) | CSD Municipal | - | Iztapa | 0:0 (0:0) | ||
| 1st(1st leg): 06/05/2021 19:00 | 2nd (2nd leg): 09/05/2021 18:00 | Winner: Iztapa | ||||
| 1st(1st leg) | Cobán Imperial | - | Santa Lucía | 1:1 (1:0) | ||
| 2nd (2nd leg) | Santa Lucía | - | Cobán Imperial | 3:0 (2:0) | ||
| 1st(1st leg): 06/05/2021 22:30 | 2nd (2nd leg): 09/05/2021 21:00 | Winner: Santa Lucía | ||||
