| 1. Round | 22/01/2016 | Deportivo Capiatá | - | General Caballero ZC | 3:2 |  |
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| 2. Round | 30/01/2016 | General Caballero ZC | - | General Díaz | 5:1 | |
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| 3. Round | 04/02/2016 | Cerro Porteño | - | General Caballero ZC | 3:0 | ||||
| 13. Round | 06/04/2016 | General Díaz | - | General Caballero ZC | 1:3 | ||||
| 14. Round | 10/04/2016 | General Caballero ZC | - | Cerro Porteño | 2:4 | ||||
| 15. Round | 16/04/2016 | Sportivo Luqueño | - | General Caballero ZC | 0:2 | ||||
| 16. Round | 21/04/2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Round | 27/04/2016 | General Caballero ZC | - | Guaraní | 0:1 | ||||
| 18. Round | 30/04/2016 | Club Rubio Ñu | - | General Caballero ZC | 1:2 | ||||
| 19. Round | 06/05/2016 | General Caballero ZC | - | Club Olimpia | 2:1 | ||||
| 20. Round | 08/05/2016 | Sol de América | - | General Caballero ZC | 3:3 | ||||
| 21. Round | 15/05/2016 | General Caballero ZC | - | Libertad | 0:2 | ||||
| 22. Round | 22/05/2016 | Club Nacional | - | General Caballero ZC | 2:3 |
Paraguay