| 1. Round | 12/07/2022 | Deportivo Guadalajara [Women] | - | Club Tijuana [Women] | 2:1 | ||||
| 3. Round | 24/07/2022 | Atlético San Luis [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 4. Round | 29/07/2022 | Deportivo Guadalajara [Women] | - | Gallos Blancos [Women] | 2:0 | ||||
| 5. Round | 01/08/2022 | CF Pachuca [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 6. Round | 08/08/2022 | Deportivo Guadalajara [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 7. Round | 13/08/2022 | Atlas Guadalajara [Women] | - | Deportivo Guadalajara [Women] | 1:3 | ||||
| 8. Round | 19/08/2022 | Deportivo Guadalajara [Women] | - | Santos Laguna [Women] | 3:1 | ||||
| 9. Round | 26/08/2022 | FC Juárez [Women] | - | Deportivo Guadalajara [Women] | 1:0 | ||||
| 11. Round | 11/09/2022 | Puebla FC [Women] | - | Deportivo Guadalajara [Women] | 2:3 | ||||
| 13. Round | 23/09/2022 | Pumas UNAM [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 16. Round | 18/10/2022 | CF Monterrey [Women] | - | Deportivo Guadalajara [Women] | 1:0 |
Mexico