| 1. Round | 18/10/2020 | Guaireña FC | - | Libertad | 0:3 | ||||
| 3. Round | 31/10/2020 | Cerro Porteño | - | Libertad | 1:0 |  |
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| 4. Round | 07/11/2020 | Libertad | - | River Plate | 3:1 | ||||
| 5. Round | 10/11/2020 | General Díaz | - | Libertad | 3:4 | ||||
| 6. Round | 15/11/2020 | Libertad | - | Club Nacional | 0:2 | ||||
| 8. Round | 29/11/2020 | Libertad | - | 12 de Octubre de Itauguá | 3:0 | ||||
| 9. Round | 05/12/2020 | Sportivo Luqueño | - | Libertad | 2:2 | ||||
| 10. Round | 11/12/2020 | Libertad | - | Guaraní | 1:1 | |
Paraguay