| 3. Round | 15/02/2021 | Libertad | - | Cerro Porteño | 2:1 |  |
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| 6. Round | 05/03/2021 | 12 de Octubre de Itauguá | - | Libertad | 2:1 | |
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| 11. Round | 12/04/2021 | Libertad | - | Guaireña FC | 2:1 | ||||
| 12. Round | 18/04/2021 | Cerro Porteño | - | Libertad | 0:3 | |
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| 13. Round | 26/04/2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Round | 04/05/2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Round | 09/05/2021 | Libertad | - | 12 de Octubre de Itauguá | 3:1 |
Paraguay