| 1. Round | 25/07/2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Round | 01/08/2021 | Vorskla Poltava | - | Rukh Lviv | 2:0 | ||||
| 3. Round | 07/08/2021 | Rukh Lviv | - | NK Veres | 2:1 | ||||
| 4. Round | 15/08/2021 | Kolos Kovalivka | - | Rukh Lviv | 1:1 | ||||
| 5. Round | 21/08/2021 | SK Dnipro-1 | - | Rukh Lviv | 2:0 | ||||
| 6. Round | 29/08/2021 | Rukh Lviv | - | FK Lviv | 1:0 | ||||
| 7. Round | 11/09/2021 | Rukh Lviv | - | Zorya Lugansk | 1:1 | ||||
| 8. Round | 17/09/2021 | Desna Chernigov | - | Rukh Lviv | 1:0 | ||||
| 9. Round | 25/09/2021 | Rukh Lviv | - | Dinamo Kiev | 0:2 | ||||
| 10. Round | 01/10/2021 | FK Mariupol | - | Rukh Lviv | 0:2 | ||||
| 14. Round | 06/11/2021 | Chernomorets Odessa | - | Rukh Lviv | 4:3 | ||||
| 15. Round | 20/11/2021 | Shakhtar Donetsk | - | Rukh Lviv | 2:0 |  |
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| 16. Round | 28/11/2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Round | 04/12/2021 | Rukh Lviv | - | Vorskla Poltava | 0:0 | |
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| 18. Round | 11/12/2021 | NK Veres | - | Rukh Lviv | 1:1 |
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