| 2. Round | 16/08/2020 | RSC Anderlecht | - | Sint-Truidense VV | 3:1 |  |
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| 3. Round | 23/08/2020 | RSC Anderlecht | - | Royal Excel Mouscron | 1:1 | ||||
| 4. Round | 28/08/2020 | KV Oostende | - | RSC Anderlecht | 2:2 | ||||
| 5. Round | 13/09/2020 | RSC Anderlecht | - | Cercle Brugge | 2:0 | ||||
| 6. Round | 19/09/2020 | Waasland-Beveren | - | RSC Anderlecht | 2:4 | ||||
| 7. Round | 27/09/2020 | RSC Anderlecht | - | KAS Eupen | 1:1 | ||||
| 8. Round | 04/10/2020 | Club Brugge KV | - | RSC Anderlecht | 3:0 | ||||
| 9. Round | 18/10/2020 | RSC Anderlecht | - | Oud-Heverlee Leuven | 2:2 | ||||
| 10. Round | 23/10/2020 | KV Kortrijk | - | RSC Anderlecht | 1:3 |  |
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| 14. Round | 29/11/2020 | RSC Anderlecht | - | Standard Liège | 0:0 | ||||
| 15. Round | 04/12/2020 | SV Zulte Waregem | - | RSC Anderlecht | 2:2 | ||||
| 16. Round | 11/12/2020 | RSC Anderlecht | - | KRC Genk | 1:0 | |
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| 18. Round | 15/12/2020 | RSC Anderlecht | - | KV Oostende | 2:1 | ||||
| 31. Round | 21/03/2021 | RSC Anderlecht | - | SV Zulte Waregem | 4:1 | ||||
| 32. Round | 05/04/2021 | Royal Antwerp FC | - | RSC Anderlecht | 1:4 | ||||
| 33. Round | 11/04/2021 | RSC Anderlecht | - | Club Brugge KV | 2:1 | ||||
| 34. Round | 18/04/2021 | Sint-Truidense VV | - | RSC Anderlecht | 0:1 | |
Ukraine