| 1. Round | 21/08/2021 | Golden Arrows | - | Maritzburg United | 2:1 |  |
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| 2. Round | 25/08/2021 | Maritzburg United | - | Sekhukhune United | 0:2 | ||||
| 3. Round | 11/09/2021 | Baroka FC | - | Maritzburg United | 0:1 |  |
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| 6. Round | 03/10/2021 | Royal AM | - | Maritzburg United | 2:1 | ||||
| 7. Round | 20/10/2021 | Maritzburg United | - | Orlando Pirates | 0:0 | ||||
| 8. Round | 23/10/2021 | Maritzburg United | - | TS Galaxy | 1:0 | ||||
| 9. Round | 03/11/2021 | Mamelodi Sundowns | - | Maritzburg United | 1:0 | ||||
| 10. Round | 07/11/2021 | Chippa United | - | Maritzburg United | 0:0 | ||||
| 11. Round | 21/11/2021 | Maritzburg United | - | Kaizer Chiefs | 0:1 | ||||
| 19. Round | 24/11/2021 | Marumo Gallants | - | Maritzburg United | 0:0 | ||||
| 12. Round | 28/11/2021 | Maritzburg United | - | AmaZulu FC | 1:1 | ||||
| 13. Round | 04/12/2021 | Moroka Swallows | - | Maritzburg United | 1:1 |  |
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| 14. Round | 07/12/2021 | Cape Town City FC | - | Maritzburg United | 3:2 | |
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| 15. Round | 12/12/2021 | Maritzburg United | - | Stellenbosch FC | 0:0 | ||||
| 16. Round | 19/12/2021 | Maritzburg United | - | Chippa United | 0:2 | ||||
| 17. Round | 22/12/2021 | Kaizer Chiefs | - | Maritzburg United | 2:0 |
South Africa