| 1. Round | 18/07/2021 | Avangard Kursk | - | FK Kaluga | 1:0 | ||||
| 2. Round | 24/07/2021 | Avangard Kursk | - | Arsenal Tula 2 | 1:4 | ||||
| 3. Round | 01/08/2021 | Avangard Kursk | - | Zenit Penza | 4:0 |  |
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| 5. Round | 15/08/2021 | Avangard Kursk | - | FK Ryazan | 0:3 | ||||
| 6. Round | 20/08/2021 | Fakel Voronezh 2 | - | Avangard Kursk | 1:2 |  |
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| 7. Round | 29/08/2021 | Salyut Belgorod | - | Avangard Kursk | 2:1 | ||||
| 9. Round | 11/09/2021 | Avangard Kursk | - | Dinamo Vladivostok | 1:2 | ||||
| 10. Round | 14/09/2021 | Avangard Kursk | - | FK Sakhalin | 2:0 | ||||
| 11. Round | 18/09/2021 | Dinamo Bryansk | - | Avangard Kursk | 0:0 | ||||
| 14. Round | 04/10/2021 | Arsenal Tula 2 | - | Avangard Kursk | 0:2 | ||||
| 16. Round | 14/10/2021 | Avangard Kursk | - | Sokol Saratov | 0:0 | ||||
| 17. Round | 19/10/2021 | FK Ryazan | - | Avangard Kursk | 1:0 | ||||
| 19. Round | 31/10/2021 | Avangard Kursk | - | Salyut Belgorod | 1:0 |
Russia