| 2. Round | 25/04/2010 | CD Chivas | - | San Jose Earthquakes | 3:2 | ||||
| 3. Round | 02/05/2010 | San Jose Earthquakes | - | Colorado Rapids | 1:0 | ||||
| 3. Round | 22/05/2010 | Seattle Sounders | - | San Jose Earthquakes | 0:1 | ||||
| 3. Round | 30/05/2010 | San Jose Earthquakes | - | Toronto FC | 1:3 | ||||
| 5. Round | 10/07/2010 | Philadelphia Union | - | San Jose Earthquakes | 1:2 | ||||
| 7. Round | 06/09/2010 | Houston Dynamo | - | San Jose Earthquakes | 1:2 | ||||
| 7. Round | 12/09/2010 | San Jose Earthquakes | - | FC Dallas | 0:0 | ||||
| 7. Round | 25/09/2010 | Toronto FC | - | San Jose Earthquakes | 2:3 | ||||
| 8. Round | 03/10/2010 | Columbus Crew | - | San Jose Earthquakes | 0:0 | ||||
| 8. Round | 10/10/2010 | D.C. United | - | San Jose Earthquakes | 0:2 | ||||
| 8. Round | 21/10/2010 | San Jose Earthquakes | - | CD Chivas | 3:0 |
USA