4. Round | 09/04/2021 | Royal Pari | - | Real Santa Cruz | 3:2 | ||||
8. Round | 12/07/2021 | Bolívar | - | Real Santa Cruz | 1:1 | ||||
9. Round | 17/07/2021 | Real Santa Cruz | - | Club Aurora | 1:1 | ||||
10. Round | 21/07/2021 | Real Tomayapo | - | Real Santa Cruz | 2:1 | ||||
11. Round | 26/07/2021 | Real Santa Cruz | - | San José | 5:0 | ||||
12. Round | 31/07/2021 | Real Santa Cruz | - | Independiente Petrolero | 2:0 | ||||
13. Round | 03/08/2021 | Nacional Potosí | - | Real Santa Cruz | 2:2 | ||||
14. Round | 07/08/2021 | Real Santa Cruz | - | Oriente Petrolero | 0:0 | ||||
15. Round | 15/08/2021 | The Strongest | - | Real Santa Cruz | 1:2 | ||||
17. Round | 23/08/2021 | Real Santa Cruz | - | Atlético Palmaflor | 1:0 | ||||
18. Round | 14/09/2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
23. Round | 25/10/2021 | Real Santa Cruz | - | Bolívar | 0:3 | ||||
25. Round | 01/11/2021 | Real Santa Cruz | - | Real Tomayapo | 2:0 | ||||
24. Round | 07/11/2021 | Club Aurora | - | Real Santa Cruz | 4:1 | ||||
26. Round | 22/11/2021 | San José | - | Real Santa Cruz | 1:2 | ||||
29. Round | 05/12/2021 | Oriente Petrolero | - | Real Santa Cruz | 2:0 |