| 4. Round | 12/08/2018 | Deportivo Guadalajara [U17] | - | Santos Laguna [U17] | 3:3 | ||||
| 5. Round | 19/08/2018 | Santos Laguna [U17] | - | UANL Tigres [U17] | 1:1 | ||||
| 6. Round | 22/08/2018 | Club Tijuana [U17] | - | Santos Laguna [U17] | 1:2 | ||||
| 7. Round | 26/08/2018 | Santos Laguna [U17] | - | Cruz Azul [U17] | 2:0 |  |
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| 8. Round | 02/09/2018 | Deportivo Toluca [U17] | - | Santos Laguna [U17] | 2:1 | ||||
| 1. Round | 19/09/2018 | Santos Laguna [U17] | - | Lobos BUAP [U17] | 3:0 | ||||
| 10. Round | 23/09/2018 | Santos Laguna [U17] | - | CD Veracruz [U17] | 3:1 | |
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| 11. Round | 29/09/2018 | Club Necaxa [U17] | - | Santos Laguna [U17] | 2:2 | ||||
| 12. Round | 05/10/2018 | Santos Laguna [U17] | - | Atlas Guadalajara [U17] | 1:0 | ||||
| 13. Round | 20/10/2018 | CF Pachuca [U17] | - | Santos Laguna [U17] | 2:1 | ||||
| 14. Round | 26/10/2018 | Santos Laguna [U17] | - | CF Monterrey [U17] | 2:2 | ||||
| 15. Round | 04/11/2018 | Gallos Blancos [U17] | - | Santos Laguna [U17] | 1:2 | ||||
| 16. Round | 11/11/2018 | Santos Laguna [U17] | - | CF América [U17] | 1:2 | ||||
| 17. Round | 25/11/2018 | Pumas UNAM [U17] | - | Santos Laguna [U17] | 3:1 |
Mexico