| 2. Round | 17/01/2021 | Santos Laguna [U20] | - | UANL Tigres [U20] | 2:0 |  |
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| 3. Round | 22/01/2021 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 2:2 |  |
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| 4. Round | 31/01/2021 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 5. Round | 06/02/2021 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 6. Round | 14/02/2021 | Santos Laguna [U20] | - | CF Monterrey [U20] | 1:2 | ||||
| 7. Round | 18/02/2021 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:4 | |
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| 8. Round | 28/02/2021 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:0 | ||||
| 9. Round | 04/03/2021 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 10. Round | 07/03/2021 | Santos Laguna [U20] | - | Club Necaxa [U20] | 1:1 | ||||
| 15. Round | 18/04/2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:2 | ||||
| 16. Round | 26/04/2021 | CF Pachuca [U20] | - | Santos Laguna [U20] | 3:1 | ||||
| 17. Round | 02/05/2021 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 | |
Mexico