| 3. Round | 05/07/2022 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 2. Round | 08/07/2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:2 |  |
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| 6. Round | 31/07/2022 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 1:1 | |
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| 1. Round | 03/08/2022 | Santos Laguna [U20] | - | CF Monterrey [U20] | 2:1 |  |
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| 7. Round | 06/08/2022 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 8. Round | 14/08/2022 | UANL Tigres [U20] | - | Santos Laguna [U20] | 2:2 | |
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| 9. Round | 18/08/2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | ||||
| 10. Round | 21/08/2022 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 16. Round | 25/08/2022 | Club Tijuana [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 12. Round | 03/09/2022 | CF Pachuca [U20] | - | Santos Laguna [U20] | 5:1 | ||||
| 13. Round | 06/09/2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 14. Round | 10/09/2022 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 5. Round | 14/09/2022 | CF América [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 15. Round | 18/09/2022 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:0 | ||||
| 4. Round | 22/09/2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 |
Mexico