| 1. Round | 13/01/2025 | CF Monterrey | - | Puebla FC | 1:1 |  |
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| 2. Round | 18/01/2025 | Puebla FC | - | Atlético San Luis | 1:2 | ||||
| 3. Round | 25/01/2025 | Cruz Azul | - | Puebla FC | 1:1 | ||||
| 4. Round | 29/01/2025 | Puebla FC | - | Mazatlán FC | 0:1 | ||||
| 5. Round | 02/02/2025 | Santos Laguna | - | Puebla FC | 0:2 | ||||
| 6. Round | 08/02/2025 | Puebla FC | - | CF América | 1:2 |  |
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| 8. Round | 22/02/2025 | Puebla FC | - | Club Tijuana | 2:0 | |
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| 9. Round | 27/02/2025 | CF Pachuca | - | Puebla FC | 2:1 | ||||
| 10. Round | 02/03/2025 | Gallos Blancos | - | Puebla FC | 2:0 | ||||
| 11. Round | 08/03/2025 | Puebla FC | - | Pumas UNAM | 1:3 |  |
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| 13. Round | 29/03/2025 | FC Juárez | - | Puebla FC | 2:0 | ||||
| 14. Round | 05/04/2025 | Puebla FC | - | UANL Tigres | 0:0 | ||||
| 15. Round | 13/04/2025 | Club León | - | Puebla FC | 1:0 | |
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| 16. Round | 16/04/2025 | Deportivo Guadalajara | - | Puebla FC | 1:0 | ||||
| 17. Round | 19/04/2025 | Puebla FC | - | Club Necaxa | 0:1 |
Colombia
Spain