| 2. Round | 15/01/2022 | Deportivo Toluca [] | - | Club Necaxa [] | 2:1 |  |
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| 3. Round | 22/01/2022 | Gallos Blancos [] | - | Deportivo Toluca [] | 1:1 | ||||
| 5. Round | 05/02/2022 | Deportivo Toluca [] | - | Cruz Azul [] | 1:1 | ||||
| 6. Round | 12/02/2022 | Puebla FC [] | - | Deportivo Toluca [] | 0:4 | |
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| 1. Round | 15/02/2022 | FC Juárez [] | - | Deportivo Toluca [] | 2:0 | ||||
| 8. Round | 26/02/2022 | CF América [] | - | Deportivo Toluca [] | 1:2 | |
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| 9. Round | 05/03/2022 | Deportivo Toluca [] | - | CF Pachuca [] | 2:4 | ||||
| 10. Round | 12/03/2022 | Deportivo Toluca [] | - | Puebla FC [] | 2:1 | ||||
| 11. Round | 19/03/2022 | Club Necaxa [] | - | Deportivo Toluca [] | 3:4 | |
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| 12. Round | 26/03/2022 | Deportivo Toluca [] | - | Gallos Blancos [] | 3:0 | |
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| 13. Round | 02/04/2022 | Cruz Azul [] | - | Deportivo Toluca [] | 1:1 | ||||
| 14. Round | 10/04/2022 | Deportivo Toluca [] | - | FC Juárez [] | 2:2 | ||||
| 16. Round | 23/04/2022 | Pumas UNAM [] | - | Deportivo Toluca [] | 3:1 | ||||
| 17. Round | 30/04/2022 | CF Pachuca [] | - | Deportivo Toluca [] | 0:2 | |
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| 15. Round | 04/05/2022 | Deportivo Toluca [] | - | CF América [] | 0:2 |
Mexico