| 1. Round | 16/04/2022 | El Nacional [U19] | - | Macará [U19] | 3:0 dec. | ||||
| 3. Round | 30/04/2022 | Mushuc Runa [U19] | - | El Nacional [U19] | 2:2 | ||||
| 4. Round | 07/05/2022 | El Nacional [U19] | - | Técnico Universitario [U19] | 3:2 |  |
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| 6. Round | 21/05/2022 | El Nacional [U19] | - | Chacaritas FC [U19] | 2:2 | |
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| 7. Round | 27/05/2022 | Cumbayá [U19] | - | El Nacional [U19] | 2:0 | ||||
| 8. Round | 04/06/2022 | Macará [U19] | - | El Nacional [U19] | 3:1 | ||||
| 10. Round | 09/07/2022 | El Nacional [U19] | - | Mushuc Runa [U19] | 0:0 | ||||
| 11. Round | 15/07/2022 | Técnico Universitario [U19] | - | El Nacional [U19] | 1:3 | ||||
| 12. Round | 23/07/2022 | El Nacional [U19] | - | América de Quito [U19] | 5:4 |  |
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| 14. Round | 06/08/2022 | El Nacional [U19] | - | Cumbayá [U19] | 2:0 | |
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Ecuador