| 2. Round | 14/03/2021 | Blooming | - | Independiente Petrolero | 2:2 | ||||
| 1. Round | 20/03/2021 | Independiente Petrolero | - | Oriente Petrolero | 1:0 |  |
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| 3. Round | 04/04/2021 | Independiente Petrolero | - | The Strongest | 2:2 | ||||
| 4. Round | 12/04/2021 | Bolívar | - | Independiente Petrolero | 1:0 | ||||
| 14. Round | 08/08/2021 | Nacional Potosí | - | Independiente Petrolero | 1:2 | ||||
| 25. Round | 01/11/2021 | Independiente Petrolero | - | Club San José | 4:0 | |
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| 27. Round | 27/11/2021 | Independiente Petrolero | - | Real Santa Cruz | 2:1 |
Bolivia