| 3. Round | 22/01/2023 | Pumas UNAM | - | Club León | 4:1 | ||||
| 4. Round | 29/01/2023 | Deportivo Toluca | - | Club León | 0:0 | ||||
| 5. Round | 04/02/2023 | Club León | - | CF Pachuca | 0:1 | ||||
| 6. Round | 10/02/2023 | Gallos Blancos | - | Club León | 0:3 |  |
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| 8. Round | 18/02/2023 | FC Juárez | - | Club León | 0:0 | ||||
| 9. Round | 28/02/2023 | Club León | - | CF Monterrey | 1:1 | ||||
| 10. Round | 04/03/2023 | Club León | - | Atlético San Luis | 2:0 |  |
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| 11. Round | 11/03/2023 | Atlas Guadalajara | - | Club León | 0:1 | ||||
| 1. Round | 25/03/2023 | Mazatlán FC | - | Club León | 1:2 | |
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| 13. Round | 02/04/2023 | CF América | - | Club León | 2:2 | ||||
| 14. Round | 09/04/2023 | Club León | - | Cruz Azul | 0:0 | ||||
| 15. Round | 16/04/2023 | Club León | - | Deportivo Guadalajara | 0:2 | ||||
| 16. Round | 22/04/2023 | Club Tijuana | - | Club León | 0:0 | ||||
| 17. Round | 01/05/2023 | Club León | - | UANL Tigres | 3:0 | |
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Mexico