1. Round | 12/09/2021 | Boston River | - | Montevideo Wanderers | 1:3 | ||||
2. Round | 17/09/2021 | Rentistas | - | Boston River | 1:2 | ||||
3. Round | 26/09/2021 | Boston River | - | Peñarol | 2:5 | ||||
4. Round | 03/10/2021 | Montevideo City Torque | - | Boston River | 4:3 | ||||
6. Round | 16/10/2021 | Nacional | - | Boston River | 3:2 | ||||
7. Round | 21/10/2021 | Boston River | - | Cerrito | 3:2 | ||||
8. Round | 24/10/2021 | Liverpool | - | Boston River | 2:2 | ||||
9. Round | 30/10/2021 | Boston River | - | River Plate | 1:2 | ||||
11. Round | 08/11/2021 | Boston River | - | Progreso | 0:0 |