| 2. Round | 29/07/2018 | Montevideo Wanderers | - | Boston River | 3:1 | ||||
| 7. Round | 02/09/2018 | Atenas | - | Boston River | 1:0 | ||||
| 8. Round | 09/09/2018 | Boston River | - | Danubio | 0:0 | ||||
| 10. Round | 23/09/2018 | Boston River | - | Rampla Juniors | 0:0 | ||||
| 11. Round | 07/10/2018 | Fénix | - | Boston River | 2:1 | ||||
| 12. Round | 14/10/2018 | Boston River | - | Nacional | 1:0 | ||||
| 13. Round | 21/10/2018 | Progreso | - | Boston River | 1:0 | ||||
| 14. Round | 28/10/2018 | Boston River | - | Defensor Sporting | 3:1 | ||||
| 15. Round | 04/11/2018 | Racing | - | Boston River | 3:0 |  |
Brazil