| 7. Round | 02/03/2025 | Cerro Porteño | - | Guaraní | 0:1 | ||||
| 9. Round | 14/03/2025 | Guaraní | - | Atlético Tembetary | 0:0 | ||||
| 10. Round | 23/03/2025 | Sportivo Luqueño | - | Guaraní | 0:1 | ||||
| 12. Round | 06/04/2025 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 13. Round | 14/04/2025 | General Caballero DJLM | - | Guaraní | 0:0 | ||||
| 14. Round | 16/04/2025 | Guaraní | - | 2 de Mayo | 0:1 | ||||
| 15. Round | 19/04/2025 | Libertad | - | Guaraní | 1:3 | ||||
| 18. Round | 10/05/2025 | Guaraní | - | Cerro Porteño | 0:2 | ||||
| 19. Round | 18/05/2025 | Guaraní | - | Sportivo Ameliano | 1:3 | ||||
| 20. Round | 21/05/2025 | Atlético Tembetary | - | Guaraní | 1:2 | ||||
| 21. Round | 24/05/2025 | Guaraní | - | Sportivo Luqueño | 2:1 |
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