| 1. Round | 31/07/2022 | Danubio | - | Cerrito | 0:0 |  |
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| 2. Round | 07/08/2022 | Danubio | - | Deportivo Maldonado | 0:0 | ||||
| 9. Round | 19/09/2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Round | 24/09/2022 | Danubio | - | River Plate | 3:0 |  |
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| 11. Round | 30/09/2022 | Cerro Largo | - | Danubio | 1:0 | ||||
| 12. Round | 08/10/2022 | Danubio | - | Fénix | 1:1 | ||||
| 13. Round | 13/10/2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Round | 16/10/2022 | Danubio | - | Albion | 3:0 | |
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| 15. Round | 23/10/2022 | Nacional | - | Danubio | 2:0 |
USA
Italy