| 7. Round | 06/08/2022 | CF Monterrey [U20] | - | Club León [U20] | 2:0 | ||||
| 9. Round | 18/08/2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 |  |
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| 10. Round | 21/08/2022 | CF Pachuca [U20] | - | Club León [U20] | 3:0 | ||||
| 11. Round | 28/08/2022 | Club León [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 12. Round | 02/09/2022 | Club Necaxa [U20] | - | Club León [U20] | 2:2 | ||||
| 13. Round | 06/09/2022 | Club León [U20] | - | FC Juárez [U20] | 3:1 | |
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| 14. Round | 10/09/2022 | UANL Tigres [U20] | - | Club León [U20] | 3:2 | ||||
| 15. Round | 18/09/2022 | Club León [U20] | - | Gallos Blancos [U20] | 3:2 | ||||
| 8. Round | 27/09/2022 | Club León [U20] | - | Mazatlán FC [U20] | 4:1 | ||||
| 17. Round | 02/10/2022 | Club León [U20] | - | Club Tijuana [U20] | 1:0 |
USA
Mexico