| 1. Round | 12/08/2022 | Excelsior Virton | - | RWD Molenbeek | 1:1 | ||||
| 2. Round | 20/08/2022 | RWD Molenbeek | - | FCV Dender EH | 1:0 |  |
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| 3. Round | 28/08/2022 | Club NXT | - | RWD Molenbeek | 2:1 | ||||
| 4. Round | 02/09/2022 | RWD Molenbeek | - | RSCA Futures | 2:2 | ||||
| 5. Round | 11/09/2022 | KMSK Deinze | - | RWD Molenbeek | 1:2 | ||||
| 6. Round | 17/09/2022 | RWD Molenbeek | - | KRC Genk II | 1:1 | ||||
| 9. Round | 14/10/2022 | Standard Liège II | - | RWD Molenbeek | 1:4 | ||||
| 10. Round | 23/10/2022 | RWD Molenbeek | - | SK Beveren | 3:1 | |
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| 11. Round | 30/10/2022 | RWD Molenbeek | - | Lierse Kempenzonen | 3:0 | ||||
| 12. Round | 04/11/2022 | FCV Dender EH | - | RWD Molenbeek | 0:1 | ||||
| 13. Round | 13/11/2022 | RWD Molenbeek | - | Lommel SK | 5:0 | ||||
| 14. Round | 19/11/2022 | SK Beveren | - | RWD Molenbeek | 1:1 | |
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| 15. Round | 25/11/2022 | KRC Genk II | - | RWD Molenbeek | 2:0 | ||||
| 16. Round | 03/12/2022 | RWD Molenbeek | - | Club NXT | 0:2 | |
Netherlands