2. Round | 22/02/2022 | Santiago Morning | - | Santa Cruz | 2:1 | ||||
3. Round | 01/03/2022 | Santa Cruz | - | CD Magallanes | 1:2 | ||||
4. Round | 07/03/2022 | Fernández Vial | - | Santa Cruz | 1:0 | ||||
6. Round | 23/03/2022 | Santa Cruz | - | Barnechea | 1:1 | ||||
7. Round | 03/04/2022 | Deportes Iquique | - | Santa Cruz | 2:2 | ||||
10. Round | 21/04/2022 | Rangers | - | Santa Cruz | 2:1 | ||||
11. Round | 26/04/2022 | Santa Cruz | - | Copiapó | 2:2 | ||||
12. Round | 30/04/2022 | Puerto Montt | - | Santa Cruz | 3:0 | ||||
14. Round | 12/05/2022 | Unión San Felipe | - | Santa Cruz | 2:1 | ||||
15. Round | 18/05/2022 | Santa Cruz | - | San Luis | 2:0 | ||||
16. Round | 22/05/2022 | Melipilla | - | Santa Cruz | 1:0 | ||||
5. Round | 02/06/2022 | Cobreloa | - | Santa Cruz | 1:0 | ||||
27. Round | 06/09/2022 | Santa Cruz | - | Rangers | 2:1 | ||||
28. Round | 13/09/2022 | Copiapó | - | Santa Cruz | 4:2 | ||||
29. Round | 26/09/2022 | Santa Cruz | - | Puerto Montt | 0:2 | ||||
30. Round | 03/10/2022 | Recoleta | - | Santa Cruz | 2:1 | ||||
31. Round | 11/10/2022 | Santa Cruz | - | Unión San Felipe | 4:0 | ||||
32. Round | 16/10/2022 | San Luis | - | Santa Cruz | 0:0 | ||||
33. Round | 24/10/2022 | Santa Cruz | - | Melipilla | 2:1 | ||||
34. Round | 02/11/2022 | Santiago Wanderers | - | Santa Cruz | 2:0 |