| 2. Round | 25/07/2018 | Nacional Potosí | - | Destroyers | 0:0 | ||||
| 4. Round | 02/08/2018 | The Strongest | - | Destroyers | 4:1 | ||||
| 5. Round | 04/08/2018 | Destroyers | - | Jorge Wilstermann | 0:0 | ||||
| 7. Round | 19/08/2018 | Destroyers | - | Club San José | 3:0 |  |
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| 14. Round | 07/10/2018 | Destroyers | - | Sport Boys Warnes | 2:3 | ||||
| 21. Round | 14/10/2018 | Club San José | - | Destroyers | 3:1 | ||||
| 17. Round | 28/10/2018 | Destroyers | - | The Strongest | 0:1 | |
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| 18. Round | 04/11/2018 | Jorge Wilstermann | - | Destroyers | 2:1 | ||||
| 19. Round | 10/11/2018 | Destroyers | - | CD Guabirá | 1:2 | ||||
| 23. Round | 17/11/2018 | Royal Pari | - | Destroyers | 1:1 | |
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| 20. Round | 24/11/2018 | Real Potosí | - | Destroyers | 3:2 | ||||
| 22. Round | 04/12/2018 | Destroyers | - | Oriente Petrolero | 0:0 | ||||
| 24. Round | 09/12/2018 | Destroyers | - | Bolívar | 0:2 | ||||
| 26. Round | 19/12/2018 | Destroyers | - | Universitario de Sucre | 1:1 | |
Bolivia