| 1. Round | 14/08/2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 3. Round | 27/08/2021 | RWD Molenbeek | - | Excelsior Virton | 0:0 | ||||
| 4. Round | 12/09/2021 | Lierse Kempenzonen | - | RWD Molenbeek | 4:1 | ||||
| 5. Round | 17/09/2021 | RWD Molenbeek | - | Waasland-Beveren | 1:3 |  |
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| 6. Round | 25/09/2021 | RWD Molenbeek | - | Lommel SK | 1:2 | ||||
| 7. Round | 03/10/2021 | KMSK Deinze | - | RWD Molenbeek | 1:2 | ||||
| 8. Round | 17/10/2021 | RWD Molenbeek | - | KVC Westerlo | 1:2 | |
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| 14. Round | 04/12/2021 | Waasland-Beveren | - | RWD Molenbeek | 2:3 | ||||
| 16. Round | 19/12/2021 | Lierse Kempenzonen | - | RWD Molenbeek | 0:1 |
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