| 3. Round | 13/05/2018 | Rio Grande Valley FC | - | San Antonio FC | 0:0 | ||||
| 4. Round | 05/06/2018 | Real Monarchs SLC | - | Rio Grande Valley FC | 2:0 | ||||
| 4. Round | 10/06/2018 | Rio Grande Valley FC | - | Portland Timbers 2 | 0:1 | ||||
| 4. Round | 17/06/2018 | OKC Energy FC | - | Rio Grande Valley FC | 3:1 | ||||
| 4. Round | 24/06/2018 | Rio Grande Valley FC | - | Phoenix Rising | 0:0 | ||||
| 4. Round | 01/07/2018 | Saint Louis FC | - | Rio Grande Valley FC | 0:0 | ||||
| 5. Round | 08/07/2018 | Rio Grande Valley FC | - | Tulsa Roughnecks | 1:1 | ||||
| 5. Round | 15/07/2018 | Rio Grande Valley FC | - | Las Vegas Lights FC | 2:0 | ||||
| 7. Round | 09/09/2018 | Rio Grande Valley FC | - | Real Monarchs SLC | 2:1 | ||||
| 7. Round | 16/09/2018 | Colorado Springs Switchbacks | - | Rio Grande Valley FC | 1:1 | ||||
| 7. Round | 23/09/2018 | Rio Grande Valley FC | - | Seattle Sounders 2 | 3:0 | ||||
| 7. Round | 30/09/2018 | Rio Grande Valley FC | - | Fresno FC | 2:1 | ||||
| 8. Round | 14/10/2018 | San Antonio FC | - | Rio Grande Valley FC | 1:1 |
USA