| 1. Round | 12/01/2025 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 3. Round | 26/01/2025 | Deportivo Guadalajara | - | UANL Tigres | 1:1 | ||||
| 4. Round | 29/01/2025 | Club León | - | Deportivo Guadalajara | 2:1 | ||||
| 5. Round | 01/02/2025 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 | ||||
| 6. Round | 10/02/2025 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 9. Round | 27/02/2025 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | ||||
| 11. Round | 09/03/2025 | Deportivo Guadalajara | - | CF América | 0:0 |  |
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| 13. Round | 30/03/2025 | Deportivo Guadalajara | - | Cruz Azul | 0:1 | ||||
| 14. Round | 06/04/2025 | CF Monterrey | - | Deportivo Guadalajara | 3:1 | ||||
| 16. Round | 16/04/2025 | Deportivo Guadalajara | - | Puebla FC | 1:0 | ||||
| 17. Round | 20/04/2025 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 |
USA
Mexico