| 2. Round | 11/09/2021 | sc Heerenveen [U21] | - | NAC Breda [U21] | 0:1 | ||||
| 3. Round | 18/09/2021 | Almere City FC [U21] | - | sc Heerenveen [U21] | 2:1 | ||||
| 4. Round | 25/09/2021 | sc Heerenveen [U21] | - | FC Groningen [U21] | 4:2 | ||||
| 5. Round | 02/10/2021 | NEC Nijmegen [U21] | - | sc Heerenveen [U21] | 2:1 | ||||
| 6. Round | 18/10/2021 | Feyenoord [U21] | - | sc Heerenveen [U21] | 2:0 | ||||
| 8. Round | 30/10/2021 | sc Heerenveen [U21] | - | NEC Nijmegen [U21] | 0:3 | ||||
| 11. Round | 27/11/2021 | NAC Breda [U21] | - | sc Heerenveen [U21] | 2:3 | ||||
| 12. Round | 12/02/2022 | sc Heerenveen [U21] | - | ADO Den Haag [U21] | 1:1 | ||||
| 13. Round | 26/02/2022 | Twente/Heracles [U21] | - | sc Heerenveen [U21] | 1:1 |
Netherlands