| 1. Round | 14/08/2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 2. Round | 21/08/2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 3. Round | 29/08/2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 |  |
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| 7. Round | 02/10/2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 10. Round | 29/10/2021 | Excelsior Virton | - | Royal Excel Mouscron | 0:2 | ||||
| 11. Round | 06/11/2021 | Royal Excel Mouscron | - | SK Deinze | 2:0 | ||||
| 12. Round | 19/11/2021 | Waasland-Beveren | - | Royal Excel Mouscron | 0:2 | ||||
| 13. Round | 28/11/2021 | Royal Excel Mouscron | - | Lierse Kempenzonen | 2:1 | ||||
| 15. Round | 11/12/2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | ||||
| 16. Round | 18/12/2021 | SK Deinze | - | Royal Excel Mouscron | 2:2 | ||||
| 17. Round | 23/01/2022 | Royal Excel Mouscron | - | Lierse Kempenzonen | 0:0 | ||||
| 21. Round | 20/02/2022 | Royal Excel Mouscron | - | Excelsior Virton | 2:1 | ||||
| 23. Round | 06/03/2022 | Royal Excel Mouscron | - | RWD Molenbeek | 0:1 | ||||
| 26. Round | 03/04/2022 | Excelsior Virton | - | Royal Excel Mouscron | 2:0 | ||||
| 28. Round | 17/04/2022 | Waasland-Beveren | - | Royal Excel Mouscron | 2:0 |
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