2. Round | 26/07/2021 | Cerro Porteño | - | Libertad | 1:1 | ||||
3. Round | 01/08/2021 | Libertad | - | Sol de América | 1:1 | ||||
4. Round | 07/08/2021 | Club Nacional | - | Libertad | 1:0 | ||||
7. Round | 29/08/2021 | Libertad | - | Sportivo Luqueño | 5:0 | ||||
8. Round | 13/09/2021 | Libertad | - | Club Olimpia | 0:3 | ||||
9. Round | 18/09/2021 | River Plate | - | Libertad | 0:1 | ||||
11. Round | 04/10/2021 | Libertad | - | Cerro Porteño | 0:2 |