1. Round | 05/02/2022 | 12 de Octubre de Itauguá | - | Libertad | 1:6 | ||||
2. Round | 12/02/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
3. Round | 20/02/2022 | Club Olimpia | - | Libertad | 2:2 | ||||
5. Round | 06/03/2022 | Libertad | - | Sportivo Ameliano | 2:0 | ||||
6. Round | 14/03/2022 | Club Nacional | - | Libertad | 0:3 | ||||
7. Round | 20/03/2022 | Libertad | - | Guaraní | 2:0 | ||||
11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
22. Round | 03/07/2022 | Resistencia SC | - | Libertad | 0:4 |