| 2. Round | 01/09/2012 | Danubio | - | Progreso | 1:4 | ||||
| 1. Round | 09/09/2012 | Danubio | - | Liverpool | 2:2 | ||||
| 3. Round | 16/09/2012 | Danubio | - | Montevideo Wanderers | 2:4 |  |
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| 4. Round | 23/09/2012 | Juventud de Las Piedras | - | Danubio | 0:0 | ||||
| 5. Round | 30/09/2012 | Danubio | - | Peñarol | 0:0 | ||||
| 6. Round | 07/10/2012 | Nacional | - | Danubio | 2:1 | ||||
| 7. Round | 14/10/2012 | Danubio | - | El Tanque Sisley | 1:2 | ||||
| 8. Round | 21/10/2012 | Defensor Sporting | - | Danubio | 3:1 | ||||
| 9. Round | 27/10/2012 | Danubio | - | CA Cerro | 1:1 | ||||
| 10. Round | 03/11/2012 | Racing | - | Danubio | 2:2 | ||||
| 12. Round | 17/11/2012 | Danubio | - | River Plate | 0:2 | ||||
| 13. Round | 25/11/2012 | Bella Vista | - | Danubio | 2:1 |  |
Uruguay
Argentina