| 1. Round | 14/01/2024 | Deportivo Guadalajara | - | Santos Laguna | 1:1 |  |
|||
| 2. Round | 22/01/2024 | Santos Laguna | - | CF Monterrey | 0:2 | ||||
| 3. Round | 27/01/2024 | Club León | - | Santos Laguna | 3:2 | ||||
| 4. Round | 31/01/2024 | Santos Laguna | - | Puebla FC | 3:0 | ||||
| 5. Round | 05/02/2024 | Atlas Guadalajara | - | Santos Laguna | 3:0 | ||||
| 6. Round | 11/02/2024 | Santos Laguna | - | UANL Tigres | 0:3 | ||||
| 7. Round | 19/02/2024 | Pumas UNAM | - | Santos Laguna | 3:0 | ||||
| 9. Round | 22/02/2024 | Deportivo Toluca | - | Santos Laguna | 1:0 | ||||
| 8. Round | 26/02/2024 | Santos Laguna | - | Mazatlán FC | 1:0 | ||||
| 10. Round | 02/03/2024 | Gallos Blancos | - | Santos Laguna | 0:1 | ||||
| 11. Round | 10/03/2024 | Santos Laguna | - | Cruz Azul | 3:0 | ||||
| 12. Round | 16/03/2024 | Club Tijuana | - | Santos Laguna | 2:2 | ||||
| 13. Round | 01/04/2024 | FC Juárez | - | Santos Laguna | 2:1 | ||||
| 14. Round | 07/04/2024 | Santos Laguna | - | CF América | 1:1 | ||||
| 15. Round | 13/04/2024 | Club Necaxa | - | Santos Laguna | 2:0 | ||||
| 16. Round | 21/04/2024 | Santos Laguna | - | CF Pachuca | 0:2 | ||||
| 17. Round | 29/04/2024 | Santos Laguna | - | Atlético San Luis | 0:3 |
Mexico