| 1. Round | 25/01/2025 | 2 de Mayo | - | Club Nacional | 0:0 | ||||
| 2. Round | 29/01/2025 | Club Nacional | - | Libertad | 0:3 | ||||
| 3. Round | 01/02/2025 | Cerro Porteño | - | Club Nacional | 3:1 | ||||
| 10. Round | 22/03/2025 | Club Olimpia | - | Club Nacional | 0:1 | ||||
| 11. Round | 30/03/2025 | Club Nacional | - | General Caballero DJLM | 1:0 |  |
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| 12. Round | 07/04/2025 | Club Nacional | - | 2 de Mayo | 1:0 | |
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| 13. Round | 11/04/2025 | Libertad | - | Club Nacional | 1:0 | ||||
| 14. Round | 16/04/2025 | Club Nacional | - | Cerro Porteño | 1:3 | ||||
| 15. Round | 22/04/2025 | Club Nacional | - | Deportivo Recoleta | 1:1 |  |
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| 16. Round | 26/04/2025 | Guaraní | - | Club Nacional | 2:1 | ||||
| 17. Round | 04/05/2025 | Club Nacional | - | Sportivo Ameliano | 0:1 | ||||
| 18. Round | 09/05/2025 | Atlético Tembetary | - | Club Nacional | 1:2 | ||||
| 19. Round | 17/05/2025 | Club Nacional | - | Sportivo Luqueño | 4:0 | |
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| 20. Round | 20/05/2025 | Sportivo Trinidense | - | Club Nacional | 2:0 | ||||
| 22. Round | 30/05/2025 | General Caballero DJLM | - | Club Nacional | 2:4 |
Paraguay