| 2. Round | 08/08/2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:0 | ||||
| 4. Round | 22/08/2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 | ||||
| 5. Round | 30/08/2021 | CD Walter Ferretti | - | UNAN Managua | 1:1 | ||||
| 6. Round | 02/09/2021 | CD Walter Ferretti | - | Juventus Managua | 2:0 | ||||
| 7. Round | 12/09/2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 |  |
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| 3. Round | 23/09/2021 | CD Walter Ferretti | - | Diriangén FC | 2:3 | |
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| 9. Round | 27/09/2021 | CD Walter Ferretti | - | Managua FC | 0:0 | ||||
| 10. Round | 02/10/2021 | Real Madriz | - | CD Walter Ferretti | 3:1 |  |
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| 13. Round | 21/10/2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 14. Round | 25/10/2021 | UNAN Managua | - | CD Walter Ferretti | 0:1 | ||||
| 15. Round | 31/10/2021 | CD Walter Ferretti | - | H&H Export Sébaco | 2:1 | ||||
| 16. Round | 03/11/2021 | Juventus Managua | - | CD Walter Ferretti | 2:2 | ||||
| 17. Round | 19/11/2021 | CD Walter Ferretti | - | Real Estelí FC | 4:0 | ||||
| 18. Round | 22/11/2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Mexico