| 1. Round | 23/02/2020 | Deportes Valdivia | - | Santa Cruz | 1:0 | ||||
| 2. Round | 01/03/2020 | Santa Cruz | - | Rangers | 0:2 | ||||
| 4. Round | 17/03/2020 | Unión San Felipe | - | Santa Cruz | 1:1 |  |
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| 5. Round | 31/08/2020 | Santa Cruz | - | Deportes Melipilla | 2:4 | |
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| 6. Round | 06/09/2020 | Cobreloa | - | Santa Cruz | 0:1 | ||||
| 7. Round | 10/09/2020 | Santa Cruz | - | Puerto Montt | 0:1 | |
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| 8. Round | 14/09/2020 | Ñublense | - | Santa Cruz | 2:2 | ||||
| 9. Round | 20/09/2020 | Santa Cruz | - | Deportes Temuco | 0:2 | |
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| 10. Round | 23/09/2020 | San Luis | - | Santa Cruz | 0:0 | ||||
| 15. Round | 12/10/2020 | Santa Cruz | - | Deportes Copiapó | 1:4 | ||||
| 16. Round | 28/10/2020 | Puerto Montt | - | Santa Cruz | 4:1 | ||||
| 22. Round | 24/11/2020 | Santa Cruz | - | San Marcos | 0:2 | ||||
| 18. Round | 30/11/2020 | Deportes Copiapó | - | Santa Cruz | 2:0 | ||||
| 23. Round | 06/12/2020 | Deportes Temuco | - | Santa Cruz | 2:1 | ||||
| 25. Round | 14/12/2020 | Rangers | - | Santa Cruz | 4:1 | ||||
| 27. Round | 23/12/2020 | Deportes Melipilla | - | Santa Cruz | 0:0 | |
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| 26. Round | 28/12/2020 | Santa Cruz | - | Ñublense | 1:3 |
Chile