| 3. Round | 05/09/2010 | Montevideo Wanderers | - | Tacuarembó | 2:0 |  |
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| 4. Round | 19/09/2010 | Tacuarembó | - | Liverpool | 3:2 | |
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| 5. Round | 25/09/2010 | River Plate | - | Tacuarembó | 2:0 | |
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| 6. Round | 03/10/2010 | Tacuarembó | - | Miramar Misiones | 1:1 | ||||
| 7. Round | 10/10/2010 | Bella Vista | - | Tacuarembó | 3:2 | ||||
| 10. Round | 31/10/2010 | Tacuarembó | - | CA Cerro | 0:1 | ||||
| 15. Round | 05/12/2010 | Tacuarembó | - | Defensor Sporting | 1:3 |
Uruguay