| 1. Round | 18/09/2021 | Lobos Huerta | - | Club Calor | 2:1 | ||||
| 2. Round | 25/09/2021 | Club Calor | - | CD Cuautla | 1:1 | ||||
| 3. Round | 02/10/2021 | Club de Ciervos | - | Club Calor | 0:3 | ||||
| 4. Round | 09/10/2021 | Club Calor | - | Alebrijes de Oaxaca II | 1:2 | ||||
| 5. Round | 14/10/2021 | Club Calor | - | Huracanes Izcalli | 4:1 | ||||
| 6. Round | 16/10/2021 | Aguacateros CDU | - | Club Calor | 3:2 | ||||
| 7. Round | 23/10/2021 | Club Calor | - | Guerreros Xico | 2:0 |  |
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| 8. Round | 30/10/2021 | Club Calor | - | Lobos Huerta | 5:0 | ||||
| 9. Round | 07/11/2021 | CD Cuautla | - | Club Calor | 2:1 | ||||
| 10. Round | 11/11/2021 | Club Calor | - | Club de Ciervos | 4:0 | ||||
| 11. Round | 15/11/2021 | Alebrijes de Oaxaca II | - | Club Calor | 2:1 | |
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| 12. Round | 21/11/2021 | Huracanes Izcalli | - | Club Calor | 0:4 | ||||
| 13. Round | 27/11/2021 | Club Calor | - | Aguacateros CDU | 2:1 | ||||
| 14. Round | 04/12/2021 | Guerreros Xico | - | Club Calor | 1:4 | |
Mexico