| 20. Round | 15/08/2010 | San Luis | - | La Serena | 0:1 | ||||
| 23. Round | 16/09/2010 | San Luis | - | Universidad de Concepción | 1:0 | ||||
| 24. Round | 19/09/2010 | Ñublense | - | San Luis | 4:0 |  |
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| 26. Round | 03/10/2010 | Colo-Colo | - | San Luis | 3:1 | |
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| 31. Round | 13/11/2010 | San Luis | - | Universidad de Chile | 0:3 | ||||
| 32. Round | 19/11/2010 | San Luis | - | Santiago Wanderers | 3:4 |  |
Chile