| 3. Round | 11/02/2023 | General Caballero DJLM | - | Club Nacional | 0:1 | ||||
| 4. Round | 18/02/2023 | Club Nacional | - | Libertad | 1:2 | ||||
| 5. Round | 24/02/2023 | Sportivo Ameliano | - | Club Nacional | 0:0 | ||||
| 6. Round | 03/03/2023 | Club Nacional | - | Guaraní | 0:2 | ||||
| 2. Round | 08/03/2023 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 9. Round | 25/03/2023 | Cerro Porteño | - | Club Nacional | 4:1 | ||||
| 11. Round | 08/04/2023 | Club Nacional | - | Sportivo Trinidense | 0:1 | ||||
| 12. Round | 12/04/2023 | Club Nacional | - | Guaireña FC | 2:2 | ||||
| 13. Round | 16/04/2023 | Club Olimpia | - | Club Nacional | 0:1 |  |
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| 14. Round | 24/04/2023 | Club Nacional | - | General Caballero DJLM | 2:0 | ||||
| 18. Round | 19/05/2023 | Club Nacional | - | Resistencia SC | 0:0 | ||||
| 19. Round | 23/05/2023 | Sportivo Luqueño | - | Club Nacional | 0:1 | ||||
| 20. Round | 28/05/2023 | Club Nacional | - | Cerro Porteño | 2:1 | ||||
| 21. Round | 04/06/2023 | Club Nacional | - | Tacuary | 2:0 | |
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| 22. Round | 10/06/2023 | Sportivo Trinidense | - | Club Nacional | 2:1 |
Paraguay