| Group 3 | 20/04/2021 | Santos FC | - | Barcelona | 0:2 |  |
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| Group 3 | 29/04/2021 | Barcelona | - | The Strongest | 4:0 | |
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| Group 3 | 05/05/2021 | Barcelona | - | Boca Juniors | 1:0 | |
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| Group 3 | 11/05/2021 | The Strongest | - | Barcelona | 2:0 | ||||
| Group 3 | 21/05/2021 | Boca Juniors | - | Barcelona | 0:0 | ||||
| Group 3 | 27/05/2021 | Barcelona | - | Santos FC | 3:1 | ||||
| Round of 16 | 14/07/2021 | Vélez Sarsfield | - | Barcelona | 1:0 |  |
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| Round of 16 | 21/07/2021 | Barcelona | - | Vélez Sarsfield | 3:1 | ||||
| Quarter-finals | 13/08/2021 | Fluminense RJ | - | Barcelona | 2:2 | |
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| Quarter-finals | 20/08/2021 | Barcelona | - | Fluminense RJ | 1:1 | ||||
| Semi-finals | 23/09/2021 | Flamengo RJ | - | Barcelona | 2:0 | ||||
| Semi-finals | 30/09/2021 | Barcelona | - | Flamengo RJ | 0:2 |
Ecuador