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| 1st(1st leg) | Boca Juniors | - | Atlético Mineiro | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Boca Juniors | 3:1 (0:0, 0:0) pso | ||
| 1st(1st leg): 13/07/2021 23:15 | 2nd (2nd leg): 20/07/2021 23:15 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Cerro Porteño | - | Fluminense RJ | 0:2 (0:0) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Cerro Porteño | 1:0 (1:0) | ||
| 1st(1st leg): 13/07/2021 23:15 | 2nd (2nd leg): 03/08/2021 23:15 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | São Paulo FC | - | Racing Club | 1:1 (1:1) | ||
| 2nd (2nd leg) | Racing Club | - | São Paulo FC | 1:3 (0:1) | ||
| 1st(1st leg): 14/07/2021 01:30 | 2nd (2nd leg): 21/07/2021 01:30 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Universidad Católica | - | Palmeiras | 0:1 (0:1) | ||
| 2nd (2nd leg) | Palmeiras | - | Universidad Católica | 1:0 (1:0) | ||
| 1st(1st leg): 14/07/2021 23:15 | 2nd (2nd leg): 21/07/2021 23:15 | Winner: Palmeiras | ||||
| 1st(1st leg) | Vélez Sarsfield | - | Barcelona | 1:0 (1:0) | ||
| 2nd (2nd leg) | Barcelona | - | Vélez Sarsfield | 3:1 (1:0) | ||
| 1st(1st leg): 14/07/2021 23:15 | 2nd (2nd leg): 21/07/2021 23:15 | Winner: Barcelona | ||||
| 1st(1st leg) | Defensa y Justicia | - | Flamengo RJ | 0:1 (0:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Defensa y Justicia | 4:1 (1:1) | ||
| 1st(1st leg): 15/07/2021 01:30 | 2nd (2nd leg): 22/07/2021 01:30 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | River Plate | - | Argentinos Juniors | 1:1 (1:1) | ||
| 2nd (2nd leg) | Argentinos Juniors | - | River Plate | 0:2 (0:1) | ||
| 1st(1st leg): 15/07/2021 01:30 | 2nd (2nd leg): 22/07/2021 01:30 | Winner: River Plate | ||||
| 1st(1st leg) | Club Olimpia | - | Internacional | 0:0 (0:0) | ||
| 2nd (2nd leg) | Internacional | - | Club Olimpia | 4:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 16/07/2021 01:30 | 2nd (2nd leg): 23/07/2021 01:30 | Winner: Club Olimpia | ||||
