| 1. Round | 19/10/2020 | Cerro Porteño | - | Sportivo Luqueño | 2:0 | ||||
| 2. Round | 24/10/2020 | Sportivo Luqueño | - | River Plate | 2:0 | ||||
| 3. Round | 31/10/2020 | General Díaz | - | Sportivo Luqueño | 0:1 | ||||
| 4. Round | 08/11/2020 | Sportivo Luqueño | - | Club Nacional | 1:3 | ||||
| 5. Round | 12/11/2020 | San Lorenzo | - | Sportivo Luqueño | 1:2 | ||||
| 7. Round | 22/11/2020 | Sportivo Luqueño | - | Club Olimpia | 2:2 | ||||
| 9. Round | 05/12/2020 | Sportivo Luqueño | - | Libertad | 2:2 | ||||
| 10. Round | 11/12/2020 | Guaireña FC | - | Sportivo Luqueño | 1:0 | ||||
| 11. Round | 18/12/2020 | Sportivo Luqueño | - | Sol de América | 0:3 |
Paraguay